Inhibitory Action of 5-HT1A Agonist MKC-242 on Triazolam-Induced Phase Advances in Hamster Circadian Activity Rhythms
Mammalian circadian rhythms can be entrained by photic and non-photic stimuli. Although we know that non-photic entrainment interferes with photic entrainment signals, there is no information about whether photic entrainment interferes with non-photic entraining signals. We examined whether triazola...
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Elsevier,
2005-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_f0102fb7f49f44bb9bfb0d397e67a676 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shin-ichi Yokota |e author |
| 700 | 1 | 0 | |a Takahiro Moriya |e author |
| 700 | 1 | 0 | |a Shigenobu Shibata |e author |
| 245 | 0 | 0 | |a Inhibitory Action of 5-HT1A Agonist MKC-242 on Triazolam-Induced Phase Advances in Hamster Circadian Activity Rhythms |
| 260 | |b Elsevier, |c 2005-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.sc0050058 | ||
| 520 | |a Mammalian circadian rhythms can be entrained by photic and non-photic stimuli. Although we know that non-photic entrainment interferes with photic entrainment signals, there is no information about whether photic entrainment interferes with non-photic entraining signals. We examined whether triazolam (TRZ), a non-photic form of entrainment, could be attenuated by pre-treatment with (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole hydrochloride (MKC-242), a photic enhancing drug. We found that TRZ-induced phase advances in hamster behavioral circadian rhythms and the increase of locomotor activity were both significantly attenuated by MKC-242. Thus, in hamsters, the photic enhancing drug MKC-242 seemed to hinder benzodiazepine-induced non-photic entrainment. Keywords:: circadian rhythm, non-photic, benzodiazepine | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 98, Iss 1, Pp 103-106 (2005) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319322224 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/f0102fb7f49f44bb9bfb0d397e67a676 |z Connect to this object online. |