PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide

• Auteurs principaux: Saeed A. S. Al-Zuhairy (Auteur), Mahmoud H. Teaima (Auteur), Nabil A. Shoman (Auteur), Mohamed Elasaly (Auteur), Mohamed A. El-Nabarawi (Auteur), Hossam S. El-Sawy (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

AbstractA PEGylated Tween 80-functionalized chitosan-lipidic (PEG-T-Chito-Lip) nano-vesicular hybrid was developed for intranasal administration as an alternative delivery route to help improve the poor oral bioavailability of BCS class-III model/antiemetic (metoclopramide hydrochloride; MTC). The i...