Impact of Serum Platelet Count on Infertility in Polycystic Ovary Syndrome: A Retrospective Case-Control Study
Background: This study intended to investigate the correlation between insulin resistance (IR) and coagulation parameters in women with polycystic ovary syndrome (PCOS) and their effects on infertility. Methods: We retrospectively included 380 PCOS patients and 143 healthy controls between January 2...
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| Main Authors: | , , , , , |
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IMR Press,
2024-11-01T00:00:00Z.
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| Summary: | Background: This study intended to investigate the correlation between insulin resistance (IR) and coagulation parameters in women with polycystic ovary syndrome (PCOS) and their effects on infertility. Methods: We retrospectively included 380 PCOS patients and 143 healthy controls between January 2018 and January 2021. Clinical data, including age; body mass index; white blood cell (WBC), neutrophil (NE), lymphocyte (Lym), and platelet (PLT) counts; and D-dimer, plasma sex hormone, fasting blood sugar, and fasting insulin levels, were collected. The relationship between these markers and PCOS was assessed. Results: Elevated homeostatic model assessment of insulin resistance score was independently related to infertility in women with PCOS (odds ratio [OR] = 1.825, 95% confidence interval [CI]: 1.091-3.055, p = 0.022). WBC (7.29 [5.99-8.59] vs. 6.25 [5.33-7.40], p < 0.001), NE (3.91 [3.22-4.98] vs. 3.36 [2.62-4.51], p = 0.001), PLT (276 [244.5-317.5] vs. 251.5 [219.25-281.5], p < 0.001), and Lym (2.51 [2.02-3.11] vs. 2.08 [1.85-2.53], p < 0.001) counts, and D-dimer levels (0.22 [0.15-0.42] vs. 0.20 [0.12-0.31], p = 0.023) in the serum were markedly higher in PCOS patients with IR. Furthermore, multivariate logistic regression analysis revealed that increased serum PLT count (OR = 3.066, 95% CI: 1.052-8.939, p = 0.040) and BMI (OR = 5.06, 95% CI: 1.166-21.963, p = 0.030) were independently correlated with the risk of IR in PCOS patients. Moreover, increased PLT count was independently related to infertility (OR = 3.380, 95% CI: 1.272‒8.982, p = 0.015). Conclusions: Elevated PLT count serve as an independent responsible role for infertility in PCOS women with IR, which indicate that PLT count might be a potential predictive marker for infertility in PCOS women with IR. |
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| Item Description: | 0390-6663 10.31083/j.ceog5111252 |