Co-Inheritance of Sickle Cell Trait and Thalassemia Mutations in South Central Iran

• Main Authors: N Saleh-gohari (Author), M Mohammadi-Anaie (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2251-6085; 2251-6093
• Keywords: Sickle cell trait; β-thalassemia; α-thalassemia; Iran; Public aspects of medicine; RA1-1270
• Source: Iranian Journal of Public Health, Vol 41, Iss 10 (2012)

Background: We aimed to determine the incidence of co-inheritance as well as interaction of sickle cell trait (SCT) and αthal/βthal mutations in south and south central of Iran. Method: We employed a PCR and restriction fragment length polymorphism techniques to confirm diagnosis of sickle cell trait. All subjects were screened for any α/β -thalassemia mutations using a gap-polymerase chain reaction and amplification refractory mutations system. Results: Our results showed combination of sickle cell trait and β-globin mutation results in a severe clinical course of similar to sickle cell disease, while coinheritance of α-globin gene defects usually modulates the clinical course. A coexistence of sickle cell trait and α-globin gene mutation was the frequent genotype in overall samples (57. 5%). Conclusion: Sickle cell trait mainly co-inherits with α-globin gene mutation in the south and south central region of Iran. This combination modulates hematological indices and interferes with the SCT diagnosis.