Synthesis of cyclo-L-prolyl-glycine and study of its anti-parkinsonian activity

• Main Authors: Ksenia Koliasnikova (Author), Anna Golubyatnikova (Author), Alexey Rebeko (Author), Marina Vukolova (Author), Polina Povarnina (Author), Elena Kuznetsova (Author)
• Format: Bog
• Udgivet: LLC "Publisher OKI", 2019-09-01T00:00:00Z.
• Fag: article
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Summary

The aim of the work was to develop an optimal scheme for the synthesis of substance of cyclo-L-prolylglycine neuropeptide (CPG), a potential drug useful for the integrated treatment of psychiatric pathologies, including anxiety, depressive disorders and cognitive impairment. Two 4-stage CPG synthesis schemes were considered. Both schemes led to a product with the same optical purity, comparable to the overall yield and time-consuming, however, the first scheme is 2.5 times more profitable in terms of the cost of basic reagents per 100 g of product. The first scheme was selected as the basis for the development of laboratory regulations. Also for the first time the anti-parkinsonian activity of CPG (0.05 and 0.5 mg/kg intraperitoneally) on a model of haloperidol catalepsy was detected.

Emne beskrivelse

2587-7836
2686-8830
10.24411/2588-0519-2019-10051