The presence of TNF-α and TNFR1 in aseptic root resorption. A preliminary study
Background: It is hypothesised that osteoprotegerin (OPG), as an osteoclast antagonist, may offer molecular control over the process of orthodontic root resorption. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts and odont...
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| Main Authors: | , |
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| Format: | Book |
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Sciendo,
2011-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Background: It is hypothesised that osteoprotegerin (OPG), as an osteoclast antagonist, may offer molecular control over the process of orthodontic root resorption. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts and odontoclasts when given at a recommended dosage of 2.5 mg/kg. It was considered that traumatically-induced PDL inflammation produces mediators and cytokines with the ability to stimulate clast cell differentiation and counter the effects of OPG. |
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| Item Description: | 2207-7480 10.2478/aoj-2011-0013 |