Zerumbone Modulates α2A-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models

• Main Authors: Jasmine Siew Min Chia (Author), Noor Aishah Mohammed Izham (Author), Ahmad Akira Omar Farouk (Author), Mohd Roslan Sulaiman (Author), Sanam Mustafa (Author), Mark R. Hutchinson (Author), Enoch Kumar Perimal (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zerumbone has shown great potential in various pathophysiological models of diseases, particularly in neuropathic pain conditions. Further understanding the mechanisms of action is important to develop zerumbone as a potential anti-nociceptive agent. Numerous receptors and pathways function to inhib...