Computational drug discovery approaches identify mebendazole as a candidate treatment for autosomal dominant polycystic kidney disease

• Main Authors: Philip W. Brownjohn (Author), Azedine Zoufir (Author), Daniel J. O'Donovan (Author), Saatviga Sudhahar (Author), Alexander Syme (Author), Rosemary Huckvale (Author), John R. Porter (Author), Hester Bange (Author), Jane Brennan (Author), Neil T. Thompson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Autosomal dominant polycystic kidney disease (ADPKD) is a rare genetic disorder characterised by numerous renal cysts, the progressive expansion of which can impact kidney function and lead eventually to renal failure. Tolvaptan is the only disease-modifying drug approved for the treatment of ADPKD,...