Formulation, Characterization, and Cytotoxicity Evaluation of Lactoferrin Functionalized Lipid Nanoparticles for Riluzole Delivery to the Brain

• Главные авторы: Maria Inês Teixeira (Автор), Carla Martins Lopes (Автор), Hugo Gonçalves (Автор), José Catita (Автор), Ana Margarida Silva (Автор), Francisca Rodrigues (Автор), Maria Helena Amaral (Автор), Paulo C. Costa (Автор)
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• Опубликовано: MDPI AG, 2022-01-01T00:00:00Z.
• Предметы: article
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood-brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the br...