Formulation, Characterization, and Cytotoxicity Evaluation of Lactoferrin Functionalized Lipid Nanoparticles for Riluzole Delivery to the Brain

• Main Authors: Maria Inês Teixeira (Author), Carla Martins Lopes (Author), Hugo Gonçalves (Author), José Catita (Author), Ana Margarida Silva (Author), Francisca Rodrigues (Author), Maria Helena Amaral (Author), Paulo C. Costa (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood-brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the br...