First Bacteremia Due to <i>Corynebacterium gottingense</i> in an Immunocompromised Child: A Case Report, 16S rDNA-Based Phylogenetic Analyses and Review of the Literature

• Main Authors: Lucas Bouguerra (Author), Chrystelle Dupraz (Author), Chloé Plouzeau (Author), Anthony Michaud (Author), Lauranne Broutin (Author), Julie Cremniter (Author), Christophe Burucoa (Author), Maxime Pichon (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antibiotics12030528; 2079-6382
• Keywords: <i>Corynebacterium gottingense</i>; bacteremia; sepsis; 16S rDNA sequencing; phylogenetic analysis; Therapeutics. Pharmacology; RM1-950
• Source: Antibiotics, Vol 12, Iss 3, p 528 (2023)

<i>Corynebacterium gottingense</i> is a Gram-positive bacillus that has not been reported as pathogenic in pediatric patients. Herein, a case of catheter-associated bloodstream infection by <i>C. gottingense</i> in a 13-year-old immunocompromised child with febrile neutropenia induced for osteosarcoma is reported. The species was identified by Sanger sequencing of the 16s rRNA sequence of the bacterial strain and was compared phylogenetically with published sequences. As suggested in the literature, the presented strain was multi-susceptible, particularly to amoxicillin. The patient was treated with piperacillin/tazobactam for seven days in the context of a urinary co-infection, resulting in resolution of fever within 48 h and then relaunched with oral amoxicillin for 3 days (for a total of 10 days of antibiotic therapy). Phylogenetic analyses based on 16S rDNA demonstrated the complexity of the genus <i>Corynebacterium</i> spp. but failed to demonstrate a direct benefit in predicting clinical outcome based on this single information.