Copper Depletion Strongly Enhances Ferroptosis via Mitochondrial Perturbation and Reduction in Antioxidative Mechanisms

• Main Authors: Fan Li (Author), Xiaojing Wu (Author), Hongli Liu (Author), Mengqi Liu (Author), Zhengkai Yue (Author), Zhenyu Wu (Author), Lei Liu (Author), Fuchang Li (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Copper serves as a co-factor for a host of metalloenzymes, particularly cytochrome c oxidase (COX). Although it is known that impaired COX function can lead to the excessive accumulation of reactive oxygen species (ROS), the mechanisms underlying how copper depletion leads to cell damage are poorly...