Distribution, Morphological Characterization, and Resiniferatoxin-Susceptibility of Sensory Neurons That Innervate Rat Perirenal Adipose Tissue
Perirenal adipose tissue (PrAT) is a visceral adipose tissue involved in the pathogenesis of obesity and cardiovascular diseases via neural pathways. However, the origins, morphological characterization, and resiniferatoxin (RTX)-susceptibility of sensory neurons that innervate rat PrAT are yet uncl...
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Frontiers Media S.A.,
2019-03-01T00:00:00Z.
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| 001 | doaj_f13f4b1161ef4786b4cee5a89aec87d5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Bo-Xun Liu |e author |
| 700 | 1 | 0 | |a Ming Qiu |e author |
| 700 | 1 | 0 | |a Peng-Yu Zong |e author |
| 700 | 1 | 0 | |a Xu-Guan Chen |e author |
| 700 | 1 | 0 | |a Kun Zhao |e author |
| 700 | 1 | 0 | |a Yong Li |e author |
| 700 | 1 | 0 | |a Peng Li |e author |
| 700 | 1 | 0 | |a Wei Sun |e author |
| 700 | 1 | 0 | |a Xiang-Qing Kong |e author |
| 245 | 0 | 0 | |a Distribution, Morphological Characterization, and Resiniferatoxin-Susceptibility of Sensory Neurons That Innervate Rat Perirenal Adipose Tissue |
| 260 | |b Frontiers Media S.A., |c 2019-03-01T00:00:00Z. | ||
| 500 | |a 1662-5129 | ||
| 500 | |a 10.3389/fnana.2019.00029 | ||
| 520 | |a Perirenal adipose tissue (PrAT) is a visceral adipose tissue involved in the pathogenesis of obesity and cardiovascular diseases via neural pathways. However, the origins, morphological characterization, and resiniferatoxin (RTX)-susceptibility of sensory neurons that innervate rat PrAT are yet unclear. Using neural tracing, an injection of DiI (1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate) into PrAT revealed that sensory neurons that innervate PrAT reside in T9-L3 dorsal root ganglia (DRG). Peak labeling occurred in T13 and L1 DRGs. Two distinct peaks were observed in cross-sectional areas of the labeled soma, and the mean cross-sectional area was 717.1 ± 27.7 μm2. Immunofluorescence staining for transient receptor potential cation channel subfamily V member 1 (TRPV1) separated DiI-positive neurons into three subpopulations: small TRPV1-negative, small TRPV1-positive, and large TRPV1-negative. Furthermore, the injection of RTX into PrAT reduced labeled cells by 36.7% where TRPV1-positive cells were the main target of RTX denervation. These novel findings provide a structural basis for future TRPV1-dependent and TRPV1-independent studies on the sensory innervation of PrAT, which may be of interest for future therapeutic obesity treatment and intervention. | ||
| 546 | |a EN | ||
| 690 | |a perirenal adipose tissue | ||
| 690 | |a neural tracing | ||
| 690 | |a dorsal root ganglia | ||
| 690 | |a TRPV1 | ||
| 690 | |a resiniferatoxin | ||
| 690 | |a Neurosciences. Biological psychiatry. Neuropsychiatry | ||
| 690 | |a RC321-571 | ||
| 690 | |a Human anatomy | ||
| 690 | |a QM1-695 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Neuroanatomy, Vol 13 (2019) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fnana.2019.00029/full | |
| 787 | 0 | |n https://doaj.org/toc/1662-5129 | |
| 856 | 4 | 1 | |u https://doaj.org/article/f13f4b1161ef4786b4cee5a89aec87d5 |z Connect to this object online. |