Cerebroprotective Effects of the TLR4-Binding DNA Aptamer ApTOLL in a Rat Model of Ischemic Stroke and Thrombectomy Recanalization

• Main Authors: Alicia Aliena-Valero (Author), Macarena Hernández-Jiménez (Author), Mikahela A. López-Morales (Author), Eva Tamayo-Torres (Author), María Castelló-Ruiz (Author), David Piñeiro (Author), Marc Ribó (Author), Juan B. Salom (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ApTOLL, a TLR4 modulator aptamer, has demonstrated cerebroprotective effects in a permanent ischemic stroke mouse model, as well as safety and efficacy in early phase clinical trials. We carried out reverse translation research according to STAIR recommendations to further characterize the effects a...