The LepR-mediated leptin transport across brain barriers controls food reward

• Main Authors: Alessandro Di Spiezio (Author), Elvira Sonia Sandin (Author), Riccardo Dore (Author), Helge Müller-Fielitz (Author), Steffen E. Storck (Author), Mareike Bernau (Author), Walter Mier (Author), Henrik Oster (Author), Olaf Jöhren (Author), Claus U. Pietrzik (Author), Hendrik Lehnert (Author), Markus Schwaninger (Author)
• Format: Book
• Published: Elsevier, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Leptin is a key hormone in the control of appetite and body weight. Predominantly produced by white adipose tissue, it acts on the brain to inhibit homeostatic feeding and food reward. Leptin has free access to circumventricular organs, such as the median eminence, but entry into other br...