Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion
<p><strong>Background: </strong>Tuberculosis is a leading cause of worldwide preventable morbidity and mortality from an infectious agent. A defi nite diagnosis of tubercular pleural effusion can be diffi cult to make because of low sensitivity and/or specifi city of noninvasive tr...
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Association of Clinical Pathologists of Nepal,
2013-03-01T00:00:00Z.
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| Summary: | <p><strong>Background: </strong>Tuberculosis is a leading cause of worldwide preventable morbidity and mortality from an infectious agent. A defi nite diagnosis of tubercular pleural effusion can be diffi cult to make because of low sensitivity and/or specifi city of noninvasive traditional diagnostic tools. This study is done to fi nd out a sensitive and specifi c marker for early diagnosis of tuberculous pleural effusion.</p> <p><strong>Materials and Methods: </strong>One hundred and three pleural effusion cases were enrolled in the study, out of which 62 were tuberculous pleural effusion cases and 49 were non-tuberculous cases.</p> <p><strong>Results: </strong>Considering 40 U/L as a cut off value for Adenosine deaminase assay level, the test result was positive in 58 out of 62 patients of tuberculosis indicating sensitivity of the test as 94%; however, among 41 non-tuberculous patients, 5 presented ADA activity level more than 40U/L, which lowers the specifi city of the test to 88%. ADA levels were signifi cantly higher in tuberculous than in non tuberculous cases (P value <0.001).</p> <p><strong>Conclusion: </strong>It may be concluded that ADA levels are signifi cantly high in patients with tuberculous pleural effusion compared to that in non tuberculous group. Sensitivity (94%) and specifi city (88%) of the test in tuberculous pleural effusions are very high, when cut off value set at 40U/L. The result indicated that the analysis of ADA levels in pleural effusion constitute a very useful marker for the diagnosis of TPE which, in addition, can be made quickly in a non- invasive way.</p> <p>Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 367-373</p> <p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v3i5.7860">http://dx.doi.org/10.3126/jpn.v3i5.7860</a></p> |
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| Item Description: | 2091-0797 2091-0908 10.3126/jpn.v3i5.7860 |