Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation

• Main Authors: Mohammed S. Taghour (Author), Hazem A. Mahdy (Author), Maher H. Gomaa (Author), Ahmed Aglan (Author), Mahmoud Gomaa Eldeib (Author), Alaa Elwan (Author), Mohammed A. Dahab (Author), Eslam B. Elkaeed (Author), Aisha A. Alsfouk (Author), Mohamed M. Khalifa (Author), Ibrahim H. Eissa (Author), Hazem Elkady (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (12d, 12f, 12i, 12l, and 13a) displayed high growth inhibitory activities against HepG2 and MCF-7 cell lines and were further investigated for...