[225Ac]Ac- and [111In]In-DOTA-trastuzumab theranostic pair: cellular dosimetry and cytotoxicity in vitro and tumour and normal tissue uptake in vivo in NRG mice with HER2-positive human breast cancer xenografts

• Κύριοι συγγραφείς: Misaki Kondo (Συγγραφέας), Zhongli Cai (Συγγραφέας), Conrad Chan (Συγγραφέας), Nubaira Forkan (Συγγραφέας), Raymond M. Reilly (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: SpringerOpen, 2023-09-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Background Trastuzumab (Herceptin) has improved the outcome for patients with HER2-positive breast cancer (BC) but brain metastases (BM) remain a challenge due to poor uptake of trastuzumab into the brain. Radioimmunotherapy (RIT) with trastuzumab labeled with α-particle emitting, 225Ac may...