Sleep Disordered Breathing in Children with Neuromuscular Disease

Sleep disordered breathing (SDB) in children with neuromuscular disease (NMD) is more prevalent compared to the general population, and often manifests as sleep-related hypoventilation, sleep-related hypoxemia, obstructive sleep apnea, central sleep apnea, and/or disordered control of breathing. Oth...

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Main Authors: Ambika G. Chidambaram (Author), Sanjay Jhawar (Author), Craig M. McDonald (Author), Kiran Nandalike (Author)
Format: Book
Published: MDPI AG, 2023-10-01T00:00:00Z.
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001 doaj_f1ade1acb4d34f59a415b1cc7780e374
042 |a dc 
100 1 0 |a Ambika G. Chidambaram  |e author 
700 1 0 |a Sanjay Jhawar  |e author 
700 1 0 |a Craig M. McDonald  |e author 
700 1 0 |a Kiran Nandalike  |e author 
245 0 0 |a Sleep Disordered Breathing in Children with Neuromuscular Disease 
260 |b MDPI AG,   |c 2023-10-01T00:00:00Z. 
500 |a 10.3390/children10101675 
500 |a 2227-9067 
520 |a Sleep disordered breathing (SDB) in children with neuromuscular disease (NMD) is more prevalent compared to the general population, and often manifests as sleep-related hypoventilation, sleep-related hypoxemia, obstructive sleep apnea, central sleep apnea, and/or disordered control of breathing. Other sleep problems include, sleep fragmentation, abnormal sleep architecture, and nocturnal seizures in certain neuromuscular diseases. The manifestation of sleep disordered breathing in children depends on the extent, type, and progression of neuromuscular weakness, and in some instances, may be the first sign of a neuromuscular weakness leading to diagnosis of an NMD. In-lab diagnostic polysomnography (PSG) remains the gold standard for the diagnosis of sleep disordered breathing in children, but poses several challenges, including access to many children with neuromuscular disease who are non-ambulatory. If SDB is untreated, it can result in significant morbidity and mortality. Hence, we aimed to perform a comprehensive review of the literature of SDB in children with NMD. This review includes pathophysiological changes during sleep, clinical evaluation, diagnosis, challenges in interpreting PSG data using American Academy of Sleep (AASM) diagnostic criteria, management of SDB, and suggests areas for future research. 
546 |a EN 
690 |a neuromuscular disease 
690 |a obstructive sleep apnea 
690 |a hypoventilation 
690 |a non-invasive mode of ventilation 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Children, Vol 10, Iss 10, p 1675 (2023) 
787 0 |n https://www.mdpi.com/2227-9067/10/10/1675 
787 0 |n https://doaj.org/toc/2227-9067 
856 4 1 |u https://doaj.org/article/f1ade1acb4d34f59a415b1cc7780e374  |z Connect to this object online.