p53 Gene Codon 72 Polymorphisms among Cervical Carcinoma Patients
Objective: To identify the association between p53 gene codon 72 polymorphism and cervical carcinoma. Method: An analytic observational study with case-control design, from November 2013 until March 2014 in the Department of Obstetrics and Gynecology and Microbiology Laboratory Faculty of Medicine,...
Sábháilte in:
| Príomhchruthaitheoirí: | , , , |
|---|---|
| Formáid: | LEABHAR |
| Foilsithe / Cruthaithe: |
Indonesian Society of Obstetrics and Gynecology,
2015-07-01T00:00:00Z.
|
| Ábhair: | |
| Rochtain ar líne: | Connect to this object online. |
| Clibeanna: |
Cuir clib leis
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_f1d634e4b9824b7d96aa1d922e98ce3f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Rustham Basyar |e author |
| 700 | 1 | 0 | |a Agustria Z Saleh |e author |
| 700 | 1 | 0 | |a Irawan Sastradinata |e author |
| 700 | 1 | 0 | |a Yuwono Yuwono |e author |
| 245 | 0 | 0 | |a p53 Gene Codon 72 Polymorphisms among Cervical Carcinoma Patients |
| 260 | |b Indonesian Society of Obstetrics and Gynecology, |c 2015-07-01T00:00:00Z. | ||
| 500 | |a 2338-6401 | ||
| 500 | |a 2338-7335 | ||
| 500 | |a 10.32771/inajog.v3i3.48 | ||
| 520 | |a Objective: To identify the association between p53 gene codon 72 polymorphism and cervical carcinoma. Method: An analytic observational study with case-control design, from November 2013 until March 2014 in the Department of Obstetrics and Gynecology and Microbiology Laboratory Faculty of Medicine, Sriwijaya University, Dr. Moh. Hoesin Hospital Palembang. Result: In total there are 100 samples analyzed consisting of 50 subjects and 50 control groups. Genotype distribution in subject group are 54% Arg/Arg, 42% Pro/Arg and 4% Pro/Pro, and in control group are 36% Arg/Arg, 46% Pro/Arg and 18% Pro/Pro. Arg/Arg genotype is at risk of cervical carcinoma 6.7 times higher compared with Pro/Pro genotype (p=0.013; OR 6.75; 95% CI 1.34-34.94). Arg allele in the p53 gene codon 72 increase the risk of cervical carcinoma 2.6 times more than Pro allele. Conclusion: Proline mutation to Arginine in gene p53 P72R is one of the risk factor for cervical carcinoma. Keywords: arginine, cervical carcinoma, gene p53 codon 72, polymorphism, proline | ||
| 546 | |a EN | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Indonesian Journal of Obstetrics and Gynecology, Pp 165-169 (2015) | |
| 787 | 0 | |n http://inajog.com/index.php/journal/article/view/48 | |
| 787 | 0 | |n https://doaj.org/toc/2338-6401 | |
| 787 | 0 | |n https://doaj.org/toc/2338-7335 | |
| 856 | 4 | 1 | |u https://doaj.org/article/f1d634e4b9824b7d96aa1d922e98ce3f |z Connect to this object online. |