Cordycepin Attenuates Neointimal Formation by Inhibiting Reactive Oxygen Species-Mediated Responses in Vascular Smooth Muscle Cells in Rats

• Main Authors: Kyung-Jong Won (Author), Su-Chan Lee (Author), Chang-Kwon Lee (Author), Hwan Myung Lee (Author), So Hee Lee (Author), Zhi Fang (Author), Ok Byung Choi (Author), Meihua Jin (Author), Junghwan Kim (Author), Taekyu Park (Author), Wahn Soo Choi (Author), Si-Kwan Kim (Author), Bokyung Kim (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We determined the action mechanism of cordycepin, a major bioactive component of Cordyceps militaris, on responses of rat aortic smooth muscle cells (RASMCs) and on vascular disorders, especially neointimal formation. Cordycepin inhibited platelet-derived growth factor-BB (PDGF-BB)-induced RASMCs mi...