Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease
Objective: Mutations to the BSCL2 gene disrupt the protein seipin and cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals exhibit a near complete loss of white adipose tissue (WAT) and suffer from metabolic disease. Seipin is critical for adipocyte developm...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2018-04-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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