Involvement of NMDA-AKT-mTOR Signaling in Rapid Antidepressant-Like Activity of Chaihu-jia-Longgu-Muli-tang on Olfactory Bulbectomized Mice

• Main Authors: Xing Wang (Author), Zhilu Zou (Author), Qinqin Shen (Author), Zhiheng Huang (Author), Jie Chen (Author), Juanjuan Tang (Author), Wenda Xue (Author), Weiwei Tao (Author), Haoxin Wu (Author), Dawei Wang (Author), Gang Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Fast-onset antidepressants are urgently needed. Chaihu-jia-Longgu-Muli-tang (CLM), a classic Chinese herbal medicine, has been used for antidepressant treatment with long history. Olfactory bulbectomization (OB) model is validated for identification of rapid antidepressant efficacy. Here...