New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity

• Main Authors: Veronika Talianová (Author), Zdeněk Kejík (Author), Robert Kaplánek (Author), Kateřina Veselá (Author), Nikita Abramenko (Author), Lukáš Lacina (Author), Karolína Strnadová (Author), Barbora Dvořánková (Author), Pavel Martásek (Author), Michal Masařík (Author), Magdalena Houdová Megová (Author), Petr Bušek (Author), Jana Křížová (Author), Lucie Zdražilová (Author), Hana Hansíková (Author), Erik Vlčák (Author), Vlada Filimonenko (Author), Aleksi Šedo (Author), Karel Smetana (Author), Milan Jakubek (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IL-6 signaling is involved in the pathogenesis of a number of serious diseases, including chronic inflammation and cancer. Targeting of IL-6 receptor (IL-6R) by small molecules is therefore an intensively studied strategy in cancer treatment. We describe the design, synthesis, and characteristics of...