Immunotropic effects of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) in humans exposed to the factors of the accident at the Chоrnobyl nuclear power plant

• Main Authors: Igor Kuchma (Author), Anatoliy Gozhenko (Author), Volodymyra Bilas (Author), Sofiya Ruzhylo (Author), Galyna Kovalchuk (Author), Yaryna Nahurna (Author), Walery Zukow (Author), Igor Popovych (Author)
• Format: Book
• Published: Kazimierz Wielki University, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p class="MsoNormal" style="text-align: justify; text-justify: inter-ideograph;" align="justify"><strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Background.</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> In previous studies, we found that nitrogenous metabolites exhibit significant immunotropic activity, both suppressor and enhancing, at healthy rats.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">The </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">purpose</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> of this and our subsequent research is to elucidate the links between nitrogenous metabolites and immune parameters in different categories of people, both healthy and sick.</span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;"> Material and methods</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. The object of observation in 1997 were 19 men and 3 women who were exposed to pathogenic factors of the accident at the Ch</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">о</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">rnobyl nuclear power plant during the liquidation of its consequences in 1986-87. The survey was conducted twice - on admission and after two weeks of rehabilitation at the Truskavets' Spa</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">The plasma and urinary concentration of the nitrogenous metabolites were determined</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Immune status was assessed on tests of I and II levels according to the WHO memorandum.</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Results</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Both negative and positive metabolic-immune correlations were revealed.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Calculation of multiple correlation coefficients between individual metabolite parameters and constellations of immune parameters revealed the maximum immunotropic effect of Urea</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> urine (R=0,756)</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">.</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">This is followed by Uric acid plasma (R=0,727) and urine (R=0,691), Urea plasma (R=0,622), Creatinine plasma (R=0,588), Bilirubinemia (R=0,546) and Creatinine urine (R=0,510). The canonical correlation between the constellation of nitrogenous metabolites, on the one hand, and the parameters of immunity, on the other hand, was very strong</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">: </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">R=0,971; χ</span>^{<span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">2</span>}_{<span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: sub;">(15)</span>}<span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">=239; p<10</span>^{<span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">-5</span>}<span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Conclusion</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. Nitrogenous metabolites have immunomodulatory effects, both suppressor and enhancing,</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">both in healthy rats and in humans exposed to pathogenic influences.</span></p>

Item Description

2391-8306
10.12775/JEHS.2020.10.12.031