Ameliorating Effect of Oral Guggulsterone Administration in Imiquimod-Induced Psoriasis in Mice

Psoriasis is a common chronic skin condition characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. In this work, psoriasis was induced by an imiquimod 5% cream, an immune response modifier that can induce psoriasis-like skin inflammation whe...

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Bibliographic Details
Main Authors: Raghad A. Khaleel (Author), Munaf H. Zalzala (Author)
Format: Book
Published: College of Pharmacy University of Baghdad, 2018-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Raghad A. Khaleel  |e author 
700 1 0 |a Munaf H. Zalzala  |e author 
245 0 0 |a Ameliorating Effect of Oral Guggulsterone Administration in Imiquimod-Induced Psoriasis in Mice 
260 |b College of Pharmacy University of Baghdad,   |c 2018-12-01T00:00:00Z. 
500 |a 10.31351/vol27iss2pp15-23 
500 |a 2521-3512 
500 |a 1683-3597 
520 |a Psoriasis is a common chronic skin condition characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. In this work, psoriasis was induced by an imiquimod 5% cream, an immune response modifier that can induce psoriasis-like skin inflammation when applied topically in mice. Guggulsterone prepared as a suspension and has been orally given to mice before imiquimod application. The results of the current study showed that guggulsterone suspension can significantly reduce psoriasis area and severity index in (guggul suspension+imiquimod group as compared with both control group and (vehicle suspension+imiquimod ) group.   
546 |a EN 
690 |a Psoriasis, Guggulsterone, Imiquimod5%, NF-Kb, TNF-?, IL-23, IL17. 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Iraqi Journal of Pharmaceutical Sciences, Vol 27, Iss 2 (2018) 
787 0 |n https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/860 
787 0 |n https://doaj.org/toc/2521-3512 
787 0 |n https://doaj.org/toc/1683-3597 
856 4 1 |u https://doaj.org/article/f30a163c2bb241c78cde32b45de1be1e  |z Connect to this object online.