Electrochemical sensor based on multi-walled carbon nanotubes and 4-(((4-mercaptophenyl)imino)methyl) benzene-1,2-diol for simultaneous determination of epinephrine in the presence of acetaminophen

• Main Authors: Roghayyeh Aghaei (Author), Mohammad Mazloum-Ardakani (Author), Mohammad Abdollahi-Alibeik (Author), Ali Moaddeli (Author)
• Format: Book
• Published: Shiraz University of Medical Sciences, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2423-5652
• Keywords: Pharmacy and materia medica; RS1-441
• Source: Trends in Pharmaceutical Sciences, Vol 4, Iss 3, Pp 139-148 (2018)

A carbon paste electrode modified with 4-(((4-mercaptophenyl)imino)methyl)benzene-1,2-diol (MIB) and multi-walled carbon nanotubes MIB /CNT/CPE) was prepared for determination of epinefrine (EP) in the presence of acetaminophen (AC). Cyclic voltammetry, chronoamperometry and differential pulse voltammetry (DPV) techniques were used to investigate the modified electrode for the electrocatalytic oxidation of (EP) and (AC) in aqueous solutions. The separation of the oxidation peak potential for EP- AC was 200 mV. Under the optimum conditions, the calibration curve for EP was obtained in the range of 1.0 to 25.0 µM and 25.0 to 500.0 µM. The diffusion coefficient for the oxidation of EP at the surface of modified electrode was calculated as 5.76×10-5 cm2s-1.