Diagnostic biomarkers for periodontitis (observational case-control study)

• Main Authors: Ayat Mohammed (Author), Raghad Fadhil (Author), Maha Sh Mahmood (Author), Haider A Al-Waeli (Author)
• Format: Book
• Published: College of Dentistry/ University of Baghdad, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.26477/jbcd.v36i2.3673; 1817-1869; 2311-5270
• Keywords: periodontitis, ICTP, deoxypyridinoline, diagnosis; Dentistry; RK1-715
• Source: Journal of Baghdad College of Dentistry, Vol 36, Iss 2 (2024)

Background: Early detection of periodontal tissue loss prevents further development and halts additional damage. The purpose of this study was to investigate the diagnostic ability of salivary Pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP) and deoxypyridinoline (DPD) in differentiating periodontitis from periodontal health. Material and method: A case-control included 80 participants who were divided into two groups: 40 periodontitis patients and 40 subjects with a healthy periodontium. Salivary samples were collected from each patient, followed by a clinical examination. The collected saliva samples were centrifuged and frozen at -80⁰C until analysis using Enzyme-Linked Immunosorbent Assay. Results: the results indicated that both biomarkers were effective in diagnosis periodontitis. The area under the curve (AUC) for ICTP was 0.99 and the proposed cut-off point was 6.6 ng/ml, while for DPD the AUC was 0.95 and the proposed cut-off point was 211.5 nmol/L. Conclusion: Salivary ICTP and DPD demonstrated diagnostic ability in distinguishing periodontitis from a healthy periodontium, making them valuable tools in early detection and management of periodontal diseases.