CD8+ T cells as a source of IFN-γ production in human cutaneous leishmaniasis.

• Main Authors: Mahmoud Nateghi Rostami (Author), Hossein Keshavarz (Author), Rosita Edalat (Author), Abdolfattah Sarrafnejad (Author), Tahereh Shahrestani (Author), Fereidoun Mahboudi (Author), Ali Khamesipour (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: In human leishmaniasis Th1/Th2 dichotomy similar to murine model is not clearly defined and surrogate marker(s) of protection is not yet known. In this study, Th1/Th2 cytokines (IL-5, IL-10, IL-13 and IFN-γ) profile induced by purified CD4(+)/CD8(+) T cells in response to Leishmania anti...