2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach.

• Main Authors: Luke Mercer (Author), Tana Bowling (Author), Joe Perales (Author), Jennifer Freeman (Author), Tien Nguyen (Author), Cyrus Bacchi (Author), Nigel Yarlett (Author), Robert Don (Author), Robert Jacobs (Author), Bakela Nare (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: There is an urgent need to develop new, safe and effective treatments for human African trypanosomiasis (HAT) because current drugs have extremely poor safety profiles and are difficult to administer. Here we report the discovery of 2,4-diaminopyrimidines, exemplified by 4-[4-amino-5-(2-...