Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth

• Main Authors: Dawit A. Gonçalves (Author), Wilian A. Silveira (Author), Leandro H. Manfredi (Author), Flávia A. Graça (Author), Andrea Armani (Author), Enrico Bertaggia (Author), Brian T. O´Neill (Author), Natalia Lautherbach (Author), Juliano Machado (Author), Leonardo Nogara (Author), Marcelo G. Pereira (Author), Diletta Arcidiacono (Author), Stefano Realdon (Author), C. Ronald Kahn (Author), Marco Sandri (Author), Isis C. Kettelhut (Author), Luiz Carlos C. Navegantes (Author)
• Format: Book
• Published: Wiley, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Stimulation of β2‐adrenoceptors can promote muscle hypertrophy and fibre type shift, and it can counteract atrophy and weakness. The underlying mechanisms remain elusive. Methods Fed wild type (WT), 2‐day fasted WT, muscle‐specific insulin (INS) receptor (IR) knockout (M‐IR−/−),...