Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib

• Main Authors: K.A. Krishnamurthy (Author), M.G.S. Rutten (Author), J.A. Hoogerland (Author), T.H. van Dijk (Author), T. Bos (Author), M. Koehorst (Author), M.P. de Vries (Author), N.J. Kloosterhuis (Author), H. Havinga (Author), B.V. Schomakers (Author), M. van Weeghel (Author), J.C. Wolters (Author), B.M. Bakker (Author), M.H. Oosterveer (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Carbohydrate Response Element Binding Protein (ChREBP) is a glucose 6-phosphate (G6P)-sensitive transcription factor that acts as a metabolic switch to maintain intracellular glucose and phosphate homeostasis. Hepatic ChREBP is well-known for its regulatory role in glycolysis, the pentose...