Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• المؤلفون الرئيسيون: Ludmila A. G. Pinho (مؤلف), Saulo G. Souza (مؤلف), Ricardo N. Marreto (مؤلف), Livia L. Sa-Barreto (مؤلف), Tais Gratieri (مؤلف), Guilherme M. Gelfuso (مؤلف), Marcilio Cunha-Filho (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2018-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...