Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Prif Awduron: Ludmila A. G. Pinho (Awdur), Saulo G. Souza (Awdur), Ricardo N. Marreto (Awdur), Livia L. Sa-Barreto (Awdur), Tais Gratieri (Awdur), Guilherme M. Gelfuso (Awdur), Marcilio Cunha-Filho (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2018-08-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...