Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Egile Nagusiak: Ludmila A. G. Pinho (Egilea), Saulo G. Souza (Egilea), Ricardo N. Marreto (Egilea), Livia L. Sa-Barreto (Egilea), Tais Gratieri (Egilea), Guilherme M. Gelfuso (Egilea), Marcilio Cunha-Filho (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2018-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...