Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Auteurs principaux: Ludmila A. G. Pinho (Auteur), Saulo G. Souza (Auteur), Ricardo N. Marreto (Auteur), Livia L. Sa-Barreto (Auteur), Tais Gratieri (Auteur), Guilherme M. Gelfuso (Auteur), Marcilio Cunha-Filho (Auteur)
• Format: Livre
• Publié: MDPI AG, 2018-08-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...