Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Príomhchruthaitheoirí: Ludmila A. G. Pinho (Údar), Saulo G. Souza (Údar), Ricardo N. Marreto (Údar), Livia L. Sa-Barreto (Údar), Tais Gratieri (Údar), Guilherme M. Gelfuso (Údar), Marcilio Cunha-Filho (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2018-08-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...