Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Autori principali: Ludmila A. G. Pinho (Autore), Saulo G. Souza (Autore), Ricardo N. Marreto (Autore), Livia L. Sa-Barreto (Autore), Tais Gratieri (Autore), Guilherme M. Gelfuso (Autore), Marcilio Cunha-Filho (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2018-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...