Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• 主要な著者: Ludmila A. G. Pinho (著者), Saulo G. Souza (著者), Ricardo N. Marreto (著者), Livia L. Sa-Barreto (著者), Tais Gratieri (著者), Guilherme M. Gelfuso (著者), Marcilio Cunha-Filho (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2018-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...