Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Үндсэн зохиолчид: Ludmila A. G. Pinho (Зохиогч), Saulo G. Souza (Зохиогч), Ricardo N. Marreto (Зохиогч), Livia L. Sa-Barreto (Зохиогч), Tais Gratieri (Зохиогч), Guilherme M. Gelfuso (Зохиогч), Marcilio Cunha-Filho (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2018-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...