Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Principais autores: Ludmila A. G. Pinho (Autor), Saulo G. Souza (Autor), Ricardo N. Marreto (Autor), Livia L. Sa-Barreto (Autor), Tais Gratieri (Autor), Guilherme M. Gelfuso (Autor), Marcilio Cunha-Filho (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2018-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...