Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Главные авторы: Ludmila A. G. Pinho (Автор), Saulo G. Souza (Автор), Ricardo N. Marreto (Автор), Livia L. Sa-Barreto (Автор), Tais Gratieri (Автор), Guilherme M. Gelfuso (Автор), Marcilio Cunha-Filho (Автор)
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• Опубликовано: MDPI AG, 2018-08-01T00:00:00Z.
• Предметы: article
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The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...