Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

• Váldodahkkit: Ludmila A. G. Pinho (Dahkki), Saulo G. Souza (Dahkki), Ricardo N. Marreto (Dahkki), Livia L. Sa-Barreto (Dahkki), Tais Gratieri (Dahkki), Guilherme M. Gelfuso (Dahkki), Marcilio Cunha-Filho (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2018-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...