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Inhibitory Effect of Chlorpromazine on RANKL-Induced Osteoclastogenesis in Mouse Bone Marrow Cells

Abstract.: Chlorpromazine (CPZ), the first widely used phenothiazine tranquilizer, is shown to inhibit the action of intracellular calmodulin (CaM) and bone resorption in vivo and in vitro. In this study, CPZ (0.63 - 10 μM) dose-dependently inhibited the formation of tartrate-resistant acid phosphat...

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Bibliographic Details
Main Authors:	Hiroharu Kawamura (Author), Michitsugu Arai (Author), Akifumi Togari (Author)
Format:	Book
Published:	Elsevier, 2011-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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