Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema

• Main Authors: Scott D. Collum (Author), Jose G. Molina (Author), Ankit Hanmandlu (Author), Weizhen Bi (Author), Mesias Pedroza (Author), Tinne C. J. Mertens (Author), Nancy Wareing (Author), Wang Wei (Author), Cory Wilson (Author), Wenchao Sun (Author), Jayakumar Rajadas (Author), Paul L. Bollyky (Author), Kemly M. Philip (Author), Dewei Ren (Author), Rajarajan A. Thandavarayan (Author), Brian A. Bruckner (Author), Yang Xia (Author), Michael R. Blackburn (Author), Harry Karmouty-Quintana (Author)
• Format: Book
• Published: The Company of Biologists, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome that predominantly affects male smokers or ex-smokers and it has a mortality rate of 55% and a median survival of 5 years. Pulmonary hypertension (PH) is a frequently fatal complication of CPFE. Despite this dismal prognosis, no curative...