Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue

• Main Authors: Colin J. Palmer (Author), Raphael J. Bruckner (Author), Joao A. Paulo (Author), Lawrence Kazak (Author), Jonathan Z. Long (Author), Amir I. Mina (Author), Zhaoming Deng (Author), Katherine B. LeClair (Author), Jessica A. Hall (Author), Shangyu Hong (Author), Peter-James H. Zushin (Author), Kyle L. Smith (Author), Steven P. Gygi (Author), Susan Hagen (Author), David E. Cohen (Author), Alexander S. Banks (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Understanding how loci identified by genome wide association studies (GWAS) contribute to pathogenesis requires new mechanistic insights. Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused...