Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice

• Main Authors: Amandine Girousse (Author), Samuel Virtue (Author), Dan Hart (Author), Antonio Vidal-Puig (Author), Peter R. Murgatroyd (Author), Etienne Mouisel (Author), Coralie Sengenès (Author), David B. Savage (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Surplus dietary fat cannot be converted into other macronutrient forms or excreted, so has to be stored or oxidized. Healthy mammals store excess energy in the form of triacylgycerol (TAG) in lipid droplets within adipocytes rather than oxidizing it, and thus ultimately gain weight. The &...