Methotrexate-conjugated zinc oxide nanoparticles exert a substantially improved cytotoxic effect on lung cancer cells by inducing apoptosis

• Main Authors: Prakriti Mishra (Author), Mohd Faizan Ali Ahmad (Author), Lamya Ahmed Al-Keridis (Author), Mohd Saeed (Author), Nawaf Alshammari (Author), Nadiyah M. Alabdallah (Author), Rohit Kumar Tiwari (Author), Afza Ahmad (Author), Mahima Verma (Author), Shireen Fatima (Author), Irfan Ahmad Ansari (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current study, we report the synthesis of methotrexate-conjugated zinc oxide nanoparticles (MTX-ZnONPs) and their high efficacy against lung cancer cells. Conjugation of MTX with ZnONPs was authenticated by UV-vis spectroscopy, dynamic light scattering (DLS), Fourier-transform infrared (FTIR)...