Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study
<p>Abstract</p> <p>Background</p> <p>Chorioamnionitis is a common underlying cause of preterm birth (PTB). It is hypothesised that polymorphisms in immunoregulatory genes influence the host response to infection and subsequent preterm birth. The relationship between his...
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| Main Authors: | , , , , , |
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| Format: | Book |
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BMC,
2005-02-01T00:00:00Z.
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Chorioamnionitis is a common underlying cause of preterm birth (PTB). It is hypothesised that polymorphisms in immunoregulatory genes influence the host response to infection and subsequent preterm birth. The relationship between histologic chorioamnionitis and 22 single nucleotide polymorphisms in 11 immunoregulatory genes was examined in a case-control study.</p> <p>Methods</p> <p>Placentas of 181 Caucasoid women with spontaneous PTB prior to 35 weeks were examined for histologic chorioamnionitis. Polymorphisms in genes <it>IL1A</it>, <it>IL1B</it>, <it>IL1RN</it>, <it>IL1R1</it>, tumour necrosis factor (<it>TNF</it>), <it>IL4</it>, <it>IL6</it>, <it>IL10</it>, transforming growth factor beta-1 (<it>TGFB1</it>), Fas (<it>TNFRSF6</it>), and mannose-binding lectin (<it>MBL2</it>) were genotyped by polymerase chain reaction and sequence specific primers. Multivariable logistic regression including demographic and genetic variables and Kaplan-Meier survival analyses of genotype frequencies and pregnancy outcome were performed.</p> <p>Results</p> <p>Sixty-nine (34%) women had histologic evidence of acute chorioamnionitis. Carriage of the <it>IL10</it>-1082A/-819T/592A (<it>ATA</it>) haplotype [Multivariable Odds ratio (MOR) 1.9, P = 0.05] and <it>MBL2 </it>codon 54Asp allele (MOR 2.0, P = 0.04), were positively associated with chorioamnionitis, while the <it>TNFRSF6</it>-1377A/-670G (<it>AG</it>) haplotype (MOR 0.4, P = 0.03) and homozygosity for <it>TGFB1</it>-800G/509T (<it>GT</it>) haplotype (MOR 0.2, P = 0.04) were negatively associated.</p> <p>Conclusion</p> <p>These findings demonstrate that polymorphisms in immunoregulatory genes <it>IL10</it>, <it>MBL2</it>, <it>TNFRSF6 </it>and <it>TGFB1 </it>may influence susceptibility to chorioamnionitis.</p> |
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| Item Description: | 10.1186/1471-2393-5-4 1471-2393 |