Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.

• Main Authors: Vitor Coutinho Carneiro (Author), Isabel Caetano de Abreu da Silva (Author), Murilo Sena Amaral (Author), Adriana S A Pereira (Author), Gilbert Oliveira Silveira (Author), David da Silva Pires (Author), Sergio Verjovski-Almeida (Author), Frank J Dekker (Author), Dante Rotili (Author), Antonello Mai (Author), Eduardo José Lopes-Torres (Author), Dina Robaa (Author), Wolfgang Sippl (Author), Raymond J Pierce (Author), M Teresa Borrello (Author), A Ganesan (Author), Julien Lancelot (Author), Silvana Thiengo (Author), Monica Ammon Fernandez (Author), Amanda Roberta Revoredo Vicentino (Author), Marina Moraes Mourão (Author), Fernanda Sales Coelho (Author), Marcelo Rosado Fantappié (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment and control of schistosomiasis still rely on only one effective drug, praziquantel (PZQ) and, due to mass treatment, the increasing risk of selecting for schistosome strains that are resistant to PZQ has alerted investigators to the urgent need to develop novel therapeutic strategies. The...